Reddit reviews BulkSupplements.com Vitamin C Powder - Pure Ascorbic Acid (100 Grams - 3.5 oz - 133 Servings) Non-GMO - Gluten Free

I'm definitely not in favor of overpriced, heavily marketed products. Vitamin C doesn't have to be excessively priced - you can purchase ascorbic acid (Vit C) off of Amazon or any supplement store for less than $10. (Like this one - 100 servings of pure ascorbic acid for $9.99)

Regarding evidence, there actually is quite a bit of evidence (scientific studies reported in peer reviewed journals) supporting the hypothesis that Vitamin C can reduce pain and the severity of withdrawal symptoms. Here is just one of many links: https://www.ncbi.nlm.nih.gov/pubmed/10836211. If you run a pub med search for Vitamin C and opiate withdrawal you can find many more.

Further, here is a link to an article that describes these studies: https://opiateaddictionsupport.com/how-to-use-vitamin-c-for-opiate-withdrawal/. I'm not saying Vitamin C is a miracle cure, just that there is substantial evidence supporting its efficacy.

Here are a couple key quotes from that article (apologies if my formatting sucks - trying to avoid a wall of text):

> According to literature in the medical school library of the University of Mexico, Vitamin C might block the neuromodulatory response of opioid receptors to opioid drugs like heroin, morphine, oxycodone, etc. Furthermore, in vitro studies have also shown that high concentrations of Vitamin C may inhibit the endogenous opioid degrading metalloenzyme and increase endorphin levels. This is very relevant because opioids mimic endorphins. When you’re going through opiate withdrawal, you’re severely deficient in endorphins, and that’s one of the main reasons you feel so bad.
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> In a study from 2000, high doses of Vitamin C on the withdrawal syndrome of heroin abusers were investigated. The patients in the Vitamin C group received 300 mg per kg of body weight per day, along with Vitamin E in the amount of 5 mg per kg of body weight. The control group received only conventional medication.
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> The results showed that the Vitamin C group had much milder withdrawal symptoms than the control group. The study concluded that high doses of Vitamin C may ameliorate the withdrawal syndrome of heroin abusers.
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> In a study from 2008, researchers sought to study the effect of Vitamin C on the development of tolerance and dependence to opiates and it’s mechanism of action. Mice were made physically dependent on opioids from the repeated administration of morphine. Vitamin C (400-1600 mg/kg) dose dependently inhibited development of tolerance and dependence to morphine.
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> In the study, the researchers demonstrated that Vitamin C possessed antidopaminergetic activity and modulate the glutamatergic neurotransmission in mice. Opioid tolerance and dependence are thought to result form neuronal adaptations produced by repeated drug exposure, and according to the study, it is my understanding that Vitamin C appears to disrupt this mechanism.