Reddit reviews Molecular Biology of the Cell, 5th Edition
We found 17 Reddit comments about Molecular Biology of the Cell, 5th Edition. Here are the top ones, ranked by their Reddit score.
Used Book in Good Condition
We found 17 Reddit comments about Molecular Biology of the Cell, 5th Edition. Here are the top ones, ranked by their Reddit score.
Here's some lighter reading I've liked:
Readable, but more hardcore
Hardware:
Mathy:
Programmy:
Unixy:
Off the wall:
I can tell you what I think was the most importent stuff we have been doing so far in my bachelor.
BioChemistry
Cellbiology
IT Basics
Operating Systems
BioinformaticsBasics
So this is just supposed to be some kind of reference you can use to learning. You probably don't need to work through all of this.
But I strongly suggest reading about Biochemistry and Cellbiology(a nice book is Molecular Biology of the Cell) as it is really important for understanding bioinformatics.
Also give the link I posted in the Operating System part a look. Try to just use linux for a month as a lot of bioinformatics applications are written for linux and its nice to see the contrast to windows.
Regarding programming I suggest you search for a book that combines python + bioinformatics(something like this). If you want to focus on the programming part you would ideally start in ASM then switch to C then to Java and then to python.(Just to give you an impression why: ASM gives you a great insight into how the CPU works and how it acesses RAM. C is on a higher level and you start thinking about organising data and defining its structure in RAM. Java adds another layer onto that - you get objects, which make it easy for you to organize your data in blocks and there is no need for you to manage the RAM by hand with pointers like in C. But you still need to tell your variables specifically what they are. So if you have a variable that safes a Text in it you have to declare it as a string. Finally you arrived at python which is a scripting language. There is no more need for you to tell variables what they are - the compiler decides it automatically. All the annoying parts are automated. So your code becomes shorter as you don't need to type as much. The philosophy behind scripting languages is mostly to provide languages that are designed for humans not for machines).But it is kind of a overkill in your situation. Just focus on python. One final thing regarding programming just keep practicing. It is really hard at the beginning but once you get it, it starts making fun to programm as it becomes a creative way of expressing your logic.
Let's get to the bioinforamtics part. I don't think you really need to study this really hard but it's nice to be ahead of your commilitones. I recommand reading this book. You might also check out Rosalind and practice your python on some bioinformatics problems.
Edit: If you want I can send you some books as pdf files if you PM me your email adress
Molecular Biology of the cell - Great textbook to get you started. It is really comprehensive but not challenging to read. The diagrams are informative but not overbearing. The author clearly cares a great deal about the subject.
https://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/dp/0815341059
Molecular Biology - Weaver - This one is nice because it keys in on many of the landmark experiments and scientists who contributed greatly to the field:
https://www.amazon.com/Molecular-Biology-Associate-College-Sciences/dp/0073525324/ref=sr_1_1?crid=1L89I1QHNC7HX&keywords=molecular+biology+weaver&qid=1571969517&sprefix=molecular+biology+weaver%2Caps%2C130&sr=8-1
If you want something smaller and more like a narrative, give Recombinant DNA: Genes and Genomes - A Short Course a try.
https://www.amazon.com/Recombinant-DNA-Genomes-Course-Edition/dp/0716728664
Albert's Molecular Biology of the Cell. It is a very user friendly book on biology. It's pretty much considered the cream of the crop of biology and molecular biology textbooks. It will introduce you to basic science, as well as go as far in depth as you would prefer. Outside of that, journals such as Nature, Cell, Science. Good luck. Also amazon link, not to promote them, but to show what the book looks like.
http://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/dp/0815341059
I highly recommend Molecular Biology of the Cell. This is a graduate level cell/molecular bio book and goes into pretty good detail on a ton of topics. I know a ton a people with a Physics background who used this book to get a knowledge basis in bio (myself included).
Molecular biology of the cell (http://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/dp/0815341059/ref=sr_1_1?ie=UTF8&qid=1367877862&sr=8-1&keywords=molecular+biology+of+the+cell) and molecular biology of the gene (http://www.amazon.com/Molecular-Biology-Gene-James-Watson/dp/080539592X/ref=sr_1_1?s=books&ie=UTF8&qid=1367877885&sr=1-1&keywords=molecular+biology+of+the+gene) are two excellent resources for understanding genetics. If reading is what you're looking to do, begin with peer reviewed journals; textbooks become outdated quickly, but peer-reviewed journals give you a glimpse into the ideas which allowed us to better understand biological phenomena.
The best way to understand genetics is to become actively involved in such matters. Attend seminars with speakers working in cell or molecular biology fields. Get involved in research (this is by far the best thing you can do to improve your understanding of genetics).
Good luck!
This is a classic text book for molecular biology
Well if you want to learn about cell biology in general, you can't go wrong with Alberts.
Between that and Principles and review articles, you should be golden.
I'm coming from Molecular biology background so I can't really help you about medical textbooks but for the biological side of things I would recommend the following:
Biology of Aging: Observations and Principles by Arking - This was my textbook for the subject. It's really good, comprehensive book that covers methodology, basic principles and some more advanced.
An Introduction to Genetic Analysis by Griffiths - This was recommended for my Genetics class. Quite comprehensive and explains some basic genetic concepts really well (imo).
Molecular Biology of the Gene by Watson - Almost all the basic stuff from molecular biology you'll need. Essentially, The Book.
Molecular Biology of the Cell by Alberts - Cell biology, you'll need it a lot and Alberts is really good at explaining things even if it's sometimes a bit too wide.
Developmental Biology by Gilberts Developmental biology is, imo, very important and Gilberts is one of the best in the field. Definitely check it out.
There is a few more books on other subjects that are under or above this level (depending on uni this is 2nd or 3rd year of BsC) but you'll get the gist.
Considering the price of these I would recommend you to check out libgen.io (feel free to pm me if you need some help). Also you might want to check out r/longevity , it has much more traffic than this sub. I hope I wasn't confusing, I just woke up and my English is not so good in the morning. :)
I'm kinda in the same boat as you. Only I'm going for PhD so if you need any help or advice feel free to pm me. :)
The two canonical molecular bio texts are "Alberts" (Molecular Biology of the Cell by Alberts, et al) and Lodish (Molecular Cell Biology by Lodish et al).
These may not be specific enough if you want in-depth info on a particular area, but they'll get you started on just about anything you want to know.
I'm going to walk through what I think is important to know about transcription by Pol II in eukaryotes; it's similar but more complex that prokaryotes and the transcriptional mechanisms of Pol I and III are much less well understood.
First we often have a TATA box ~25bp from the transcriptional start site (TSS) where the complex of TFIID (the TF's stand for transcription factor) and TATA Binding Protein (TBP) recognize an available TATA box and bind to it.
Next a bunch of other general transcription factors arrange around the TSS and they recruit and stabilize the binding of Pol II. TFIIF then catalyzes the phosphorylation of the C-Terminal Domain (CTD) tail which causes Pol II to release from the general TFs and began transcription in the 3' -> 5' direction (thus generating transcripts in 5' - 3' orientation)
While the RNA transcript is being made capping proteins are recruited to add the 7-methylguanine cap to the 5' end of the new transcript (This serves to maintain stability and will later be a recognition site of proteins).
Additionally RNA splicing also occurs (usually) before the RNA transcript is completely transcribed. A large nuclear riboprotein (complex of nuclear RNAs and protein) call the Spliceosome uses 2 trans esterification reactions to clip out the introns and link together the exons (this is another large story I would stick with knowing what I said unless you need to know a lot about RNA splicing)
Pol II keeps elongating until it hits the stop signal in which case Pol II releases from the DNA and the RNA transcript is now ready for more precessing and then export from the nucleus.
Once the transcript is released Poly-A polymerase (PAP) adds ~200 adenosine monophosphates to the 3' end which is important for recognition by poly-A binding proteins necessary for circularization of the transcript for translation.
This is all taken from Alberts - I can send you a PDF of it if you'd like.
Edit - forgot about poly adenylation
It probably would not be a bad idea to get some knowledge of basic biology. Biochemistry, molecular biology, and genetics are probably the big three sub-disciplines you want to familiarize yourself with, but to do that you need to have a good idea of basic biology. Campell Biology is the textbook of choice for freshman biology. Molecular Biology of the Cell is a fantastic book for molecular and cellular biologists. I, unfortunately, don't know of any good books for synthetic biology itself, but these two can give you a start.
Went to med school for 4 years. Most expensive text book I spent on was ~$34 bucks That Apple book is still 20 times that.
Hey H0RSED1K it's good to hear that I'm not the only one who feels this way.
I just want to graduate as soon as possible - I'd rather spend 40 hours a week working and getting paid, then 80 hours a week studying and paying for it.
One text we used in one of my classes was great, it is Molecular Biology of the Cell
I would love to read this entire text over an 8 month period or so, and complete the problems book
I feel that this would solidify my basic knowledge in biology.
Following this I would be able to target specific areas of interest.
I'm having errors accessing my Amazon wish list, but some of the books I can remember are as follows:
Also, you can consult some of the free courses online (MIT's OCW, Coursera.org, iTunes U, Open.edu) and once you obtain the syllabus you can review the material at your leisure. There are also sites like BenchFly.com, Jove.com that have videos of lab techniques and experiments. I presently don't have the time to review these in detail, so they are on my post-graduation queue.
If you want to do this right, you'll probably have to hire a tutor to answer questions you might have.
Honestly I've never seen anything that even attempts to go over the sheer vastness of what goes on inside a cell. The best thing I can think of is to look over the movements and organization of phospholipids on the outer membrane, receptor tyrosine kinases, G-protein coupled receptors, and nuclear transcription factors. That just gives a very small sample of how many interactions the cell has with the outside environment. I know this is probably not what you're looking for, but this is currently the bible for cell/molecular biology:
http://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/dp/0815341059
http://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/dp/0815341059/ref=sr_1_1?s=books&ie=UTF8&qid=1370137610&sr=1-1
That should be a decent start. If that's too elementary I could make some other recommendations.
My gift to you