Reddit reviews The End of Food

"Less is known about the effects that sweeteners have on consumption. For decades, some researchers have argued that because humans evolved in an environment almost totally lacking in sugar and other simple sweeteners, these foods overwhelm our natural abilities to monitor intake. Scrutiny has been especially high for high-fructose corn syrup, or HFCS, which entered the food system in a big way in the late 1970s just as obesity was picking up steam, and which possess several unusual nutritional features that have been linked to obesity. First, where glucose moves easily form the blood to the brain, fructose lacks the biochemical passwords to get through the blood-brain barrier. As a result, the brain, which senses blood levels of glucose (and alters appetite accordingly), is essentially unaware of the amount of fructose circulating in the blood, and thus doesn't trigger a satiety reflex, no matter how much fructose is consumed. Second, unlike glucose, the fructose doesn't stimulate release of insulin, without which there is no leptin, which the brain needs to hear the I'm-full satiety signals from the stomach. [Third, fructose isn't fully digested until it reaches the liver. Here's fructose's unique molecular structure - particularly, the way its carbon atoms are arranged - acts as a kind of backbone for the construction of long-chain fatty acids; fructose, in other words, converts to fat more easily than other sugars do]."

Interesting read.

Edit: grammar and spelling.