Reddit reviews The Marvel Comics Guide to New York City

The problem is that practically everything Marvel-related takes place in New York.

Because, well, practically every U.S.-based fiction takes place in New York.

Oh– haha, I guess the Japanese culture stuff is not so exciting, then!
I grew up in rural America, and had a similar experience with NYC– reading Marvel comics as a kid meant I knew where a bunch of places were, though I didn't understand until I lived here why certain things were the way they were (when Peter Parker goes from his home in Flushing, Queens, to see the Fantastic Four Midtown East, for example, is laden with meaning if you know those neighborhoods!).
There are some Marvel-themed tours of NYC: here, here and here