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Doctor's Best multivitamin

It has the best form of everything (no synthetics) at a reasonable price, but you might need to limit methyl b12's depending on your VDR taq status. Check this out for more: http://methyl-nation.com/comt-vdr-taq-the-mutation-series/.

Taking one of these multis a day (says to take 3) hasn't given me any overmethylating symptoms so far. Each capsule has way more of everything compared to your average multi, so 1 should be good to shore up an otherwise healthy diet avoiding folic acid wherever you can.

Here's another idea I've been toying with and might try myself, in case you can't tolerate any methyl b12: make your own "multi" stack with minerals and a b complex, adding L-methylfolate (only need half of these) and hydroxy/adenenosyl b12 seperately if you want those. This leaves A/C/D/E/K which I believe can be pretty much covered in a healthy diet and supplemented cheaply (D+C). If you have GSTP1 mutation, you should be avoiding supplemental E.

That B complex has the best forms of the other B's and leaves out Folic Acid and B12 for us. There's another, cheaper brand on amazon without Folic Acid but it has cyano b12. I'm not sure why cyano b12 is so bad to be honest - everything I read on the net about it is kind of vague/woo-woo, but I'm erring on the side of caution anyway (at a cost to the wallet!). Perhaps you can enlighten me?

Hope this was helpful, good luck.

edit: found this on knowyourgenetics.com

>Cyano B12 contains a cyanide molecule. So when you take cyano B12 your body must first turn
it into hydroxy B12 in order to use it, and then must find a way to get rid of the toxic cyanide
molecule. We all know cyanide is a poison even if the rest of the B12 molecule is good for you.
The body actually uses hydroxy B12 in order to detoxify cyanide. So, not only is cyano B12 not
the form your body ultimately needs, but taking higher doses of cyano B12 may actually deplete
your hydroxy B12. So why would anyone use cyano B12 if it can be toxic? Well, in low doses it
may be helpful for the eyes, but for the most part cyano B12 is used because it is much less
expensive, and a form of B12 that is easier to keep stable.

Alright so honestly it sounds like as long as you get hydroxy, a little bit of cyano isn't a big deal (cyanide fears are majorly overblown reportedly). With that said I'm going to probably go with this B complex that's a much better value & low in cyano b12.

I'm not reading your post as rambling at all, actually, as it's quite specific to my interests! I also have been diagnosed with inattentive type ADHD which I've really struggled with, and symptoms I'd describe as similar to yours. Lack of motivation with a big side helping of anxiety, in my case. I wasn't able to tolerate any of the medications suggested by my P-doc, even Strattera which they give little kids. Reactions ranged from insomnia to personality changes to severe depression to, in one case a 103 degree fever! Go figure. I've had some luck with hemp oil, but sure wish I'd known I have essentially the worst case scenario for COMT mutations before I got onto the merry go round.

I don't want to get your hopes up, but I've been taking methylfolate for a couple of weeks now, a smallish dose still to be sure I could tolerate it (this is what I'm taking.) Yesterday I started supplementing with this SAM-e and.... the wire chewing feeling and dizziness (probably from hunger) went away and I feel really good! I'm noticing improvements in energy level and alertness, mostly. I'm afraid to get my own hopes up because I've had so many problems with medications generally but if this works without intolerable side effects it's going to be a life changer.

Drop me a PM or @ me here any time if you want to compare notes. I'm cutting the pills in half b/c I'm so sensitive to meds generally but hope to increase the dose before long. I'm taking 100 mg of SAM-e for now.

Update: Had to discontinue sam-E because I developed severe insomnia, and I suspect it made my PMDD worse. Also, vestibular migraines kicked up which may be a result of whatever was going on with my hormones. Will update in another month with whether I'm still having PMDD/migraine issues for any women who may try this stuff.

I had a psychiatrist recommend I take SAMe supplements. Amazon link here. I used this to successfully transition off of lexapro (which I cannot metabolize properly and was causing all sorts of problems). I've found it to be very effective.

If you have an MTHFR mutation and start taking a multivitamin, you could potentially exacerbate your issues. Everyone's body has a different clearance ratio. Those of us with an MTHFR mutation generally have slower clearances.

If all of your other levels are fine, then just continue with your current methylation protocol and simply add a good form of Zinc.

I highly recommend this Zinc

> I also can only tolerate methyl b12 in very low doses.

I have an order of this coming in tomorrow: https://www.amazon.com/gp/product/B01MQJVHHC/

Do you think it would be best to try it and see how I feel? After ordering it, I learned that some people are either over-methylating or under-methylating. My concern is the 1000mcg of Folate. I'm almost wondering if I should have had more tested before ordering the supplement. Like finding out where my B-vitamin levels are as well as methylation efficiency.

• B1 (Thiamine Mononitrate) || 25mg
  
• B2 || 25mg
  
• Niacin || 25mg
  
• B6 || 25mg
  
• Folate (as L-5-MTHFR Calcium) || 1000mcg
  
• B12 (as Methylcobalamin) || 500mcg
  
  With that said, I couldn't find any alarming reviews of the product of anyone who had bad reactions.

*I realize you had DNA testing which is how you know about these in the first place. Sorry my bad.

Here is what I take. I take two of these in the morning. An injection is much more effective and lasts a week or two, but this is an alternative.

Seeking Health | Hydroxo B12 Vitamin | Vitamin B12 Supplement | B12 Hydroxocobalamin | 60 Lozenges https://www.amazon.com/dp/B00F4G45XI/ref=cm_sw_r_cp_apa_i_SD90DbDRF1XX0

> Health Optimal Prenatal

Thank you so much, but that ended up having too much iron for me. I'll be taking SmartyPants gummies and supplementing B12 on top.

it can just don't overdo it. start with 400mcg methylfolate or less and don't go over 800mcg a day.

this is a really good b complex that isn't too excessive: https://www.amazon.com/gp/product/B00CFD0TC4/ref=oh_aui_detailpage_o01_s00?ie=UTF8&psc=1

Thank you!

Would this do?
https://www.amazon.com/gp/aw/d/B01IJR5VM2/ref=mp_s_a_1_1_a_it?ie=UTF8&qid=1540845804&sr=8-1-spons&keywords=jarrow&psc=1

https://www.amazon.com/Jarrow-Formulas-Pyridoxal-5-phosphate-Lozenges-Supports/dp/B01IJR5VM2

Just try this one today, half a pill, no effect for now, will try the dosage you suggest, thanks again!

>How did you decide on 5mg?

That's the dosage of Jarrow B12. It seems to be just the right daily dosage for me. On occasion I take more.

Whoops, I the link. Just added it above: https://www.amazon.com/gp/product/B00CFD0TC4/ref=oh_aui_detailpage_o02_s00?ie=UTF8&psc=1

https://www.amazon.fr/Intelligent-dApprovisionnement-Qualit%C3%A9-Prix-L-5-methyltetrahydrofolate-Quatrefolic/dp/B075C7M9HJ

(Much) cheaper option that I use - https://www.amazon.com/Life-Extension-Active-Complete-Complex/dp/B00DHTQNQ6/

I’m having some trouble making sense of my report. I ordered a recommended supplement on amazon (Thorne Research - Methyl-Guard Plus - Methylation Support Supplement with 5-MTHF (Folate) and Vitamins B2, B6, and B12 - 90 Capsules https://www.amazon.com/dp/B00O5AHC4S/ref=cm_sw_r_cp_api_i_Pdz7CbY7XJ2JG) but now I’m wondering if it was the right thing to get. If anyone has any insight, it would be very much appreciated! Some symptoms that might be relevant are fatigue, anxiety/OCD, depression, skin bruising, acne, and hormonal issues.

>And did you stop the b12 as well when you stopp

I was using methyl-cobalamin.


I think I stopped about the same time as I did the methyl-folate. I was using Quadrefolic I do believe.
https://www.amazon.com/ProHealth-Methylfolate-Quatrefolic-Capsules-Professional/dp/B0725HPR77/ref=sr_1_43?keywords=methylfolate&qid=1556212181&s=gateway&sr=8-43

The folate will pollute my body?

Or do you take the supplement in the picture and then take the L-Methylfolate supplement? This is the one I got from Jarrow Formulas https://www.amazon.com/Jarrow-Formulas-Methyl-Supports-Cardiovascular/dp/B007LEO3OW?th=1