Best clinical chemistry books according to redditors

Them, plus Janeway's Immunobiology, Carey and Sundberg's Advanced Organic Chemistry part A and part B, Anslyn's PhysOrg, Ptashne's A Genetic Switch, Gilbert's Developmental Biology, Fersht's Structure and Mechanism in Protein Science and the NEB Catalog form a reference shelf for Biochem/Chemical Biology that I don't suspect will need updating for another decade or two.

EDIT: Except, of course, for switching out the NEB catalog every year for the new edition.

This book might be helpful.

If you read and understood all of EJ Corey's books, then I think you should be all set for grad school.

If you are really interested in more to read, try "Advanced Organic Chemistry" by Carey.

AOC - Part A

AOC - Part B

Best of luck!

Budget? I'm in crystallography also and my boss wrote this book a few years ago "Structure Based Drug Discovery" (https://www.amazon.com/dp/1617795194/ref=cm_sw_r_cp_api_A6YoybT19FFB5). There's a chapter on protein expression but in general it's a really great book. I didn't get my PhD in crystallography and I reference it often.

Several of the comments here have made me revisit my earlier studies and I'm going to quote straight out of my text to help clarify the issue:

"The factors that influence nucleophilicity are best assessed in the context of the limiting Sn2 mechanism, since it is here that the properties of the nucleophile are most important. the rate of an Sn2 reaction is directly related to the effectiveness of the nucleophile in displacing the leaving group. In contrast, the relative nucleophilicity has no effect on the rate of an Sn1 reaction.

Many properties have an influence on nucleophilicity. Those considered to be most significant are:

1. Solvation energy of the nucleophile
   
2. Strength of the bond being formed carbon
   
3. Size of the nucleophile
   
4. Electronegativity of the attacking atom
   
5. Polarizability of the attacking atom"
   
   There are explanations in the book for each of the 5 sections, if people found this helpful I can post those as well. The text is Advance Organic Chemistry, 4th ed. by Carey and Sundberg. The newer version is available here.
   
   

Try part A of Carey & Sundberg, I highly recommend working each practice problem and reading the reference associated with each problem (there's a handy index in the back).

http://www.amazon.com/Advanced-Organic-Chemistry-Part-Mechanisms/dp/0387683461/ref=sr_1_1?ie=UTF8&qid=1419827941&sr=8-1&keywords=carey+sunberg

> https://www.amazon.com/Synthesis-Essential-Drugs-Ruben-Vardanyan/dp/0444521666

Thanks for this one, was already aware of Synthesis of Best Seller Drugs. It's on LibGen, of course.

https://www.amazon.com/Synthesis-Essential-Drugs-Ruben-Vardanyan/dp/0444521666

and a follow on book

https://www.amazon.com/Synthesis-Best-Seller-Drugs-Ruben-Vardanyan/dp/012411492X

The synthesis is not particularly sophisticated. Most of the chemicals are available in even a smaller town drug stores, agricultural supply stores, and hardware stores. You can find patent art on various methods as well, some with more exotic approaches.

This is why synthroid costs pennies per dose to make, and dimes per day to use in many countries.

The folks that are claiming this is a shit-out-of-luck situation are simply wrong. This is practically a high school chem lab exercise to succeed at in a basic way, and the path is there to purify it if required (likely not so important as the mere gross preparation of the chemical).

Most of the critical WHO pharmacopoeia is readily synthesized. These formulations only really cover about 90% of pathologic presentation (aside from mental disorders). The remaining 10% are, to a large degree, a shit-out-of-luck situation for those without resources to pay to ave them made, because they require precursors and resources that are vulnerable to degradation.

Thyroid meds are not, thankfully, in the SOL category.

I would suggest picking up a used copy of this for your lab. Despite it's age, a lot of the technique is still relevant to chemistry done today.