(Part 2) Top products from r/longevity

I'm not sure if this qualifies for what you're looking for, but I'll re-post my highlights from a few weeks ago in case it helps:

• Exercise. “In SPARK, John J. Ratey, M.D., embarks upon a fascinating and entertaining journey through the mind-body connection, presenting startling research to prove that exercise is truly our best defense against everything from depression to ADD to addiction to aggression to menopause to Alzheimer's. Filled with amazing case studies (such as the revolutionary fitness program in Naperville, Illinois, which has put this school district of 19,000 kids first in the world of science test scores), SPARK is the first book to explore comprehensively the connection between exercise and the brain. It will change forever the way you think about your morning run---or, for that matter, simply the way you think“. Source: https://www.amazon.com/Spark-Revolutionary-Science-Exercise-Brain/dp/0316113514/ref=sr_1_1?s=books&ie=UTF8&qid=1522973939&sr=1-1&keywords=Spark%2C+The+Revolutionary+New+Science+of+Exercise+and+the+Brain
  
• Eat a healthy diet and follow some of the practices taken from Blue Zones, which are populations that have an unusually high number of centenarians. Some key take-aways from studies blue zones (Source: https://www.amazon.com/product-reviews/1426216556/ref=cm_cr_dp_d_cmps_btm?ie=UTF8&reviewerType=all_reviews):
  
  • Long-lived people live on a high-carb, low-fat, plant-based diet;
    
  • Long-lived people eat a lot of vegetables, including greens;
    
  • Whenever they can get it, long-lived populations eat a lot of fruit;
    
  • When animal products are consumed, it’s occasionally and in small amounts only;
    
  • Long-lived people had periods in their life when a lot less food was available and they had to survive on a very sparse, limited diet;
    
  • Long-lived people live in a sunny, warm climate;
    
  • Long-lived people consume beans in some form or another;
    
  • Nuts appear to be good for health;
    
  • The typical diet is very simple and many essentially eat the same simple foods every day
    
  • Quality food over variety is more important;
    
  • They had an active lifestyle and moved a lot
    
  • Many of them got 5 to 6 hours of moderate exercise per day;
    
  • Many of them loved to work and had a sense of purpose in life;
    
  • Many had large families;
    
  • None of them smoked or ate massive amounts of food.
    
• Be a super-ager – “Which activities, if any, will increase your chances of remaining mentally sharp into old age? We’re still studying this question, but our best answer at the moment is: work hard at something. Many labs have observed that these critical brain regions increase in activity when people perform difficult tasks, whether the effort is physical or mental. You can therefore help keep these regions thick and healthy through vigorous exercise and bouts of strenuous mental effort.” Source: http://www.nytimes.com/2016/12/31/opinion/sunday/how-to-become-a-superager.html
  
• Boost your microbiome by eating a diverse diet. “Diet is perhaps the biggest factor in shaping the composition of the microbiome,” he says. A study by University College Cork researchers published in Nature in 2012 followed 200 elderly people over the course of two years, as they transitioned into different environments such as nursing homes. The researchers found that their subjects’ health – frailty, cognition, and immune system – all correlated with their microbiome. From bacterial population alone, researchers could tell if a patient was a long-stay patient in a nursing home, or short-stay, or living in the general community. These changes were a direct reflection of their diet in these different environments. “A diverse diet gives you a diverse microbiome that gives you a better health outcome,” says Cryan. Source: http://www.bbc.com/future/story/20140221-can-gut-bugs-make-you-smarter
  
• Have a healthy mind-set – don't ever succumb to the stereotypical mind set that getting older = decline. “To Langer, this was evidence that the biomedical model of the day — that the mind and the body are on separate tracks — was wrongheaded. The belief was that “the only way to get sick is through the introduction of a pathogen, and the only way to get well is to get rid of it,” she said, when we met at her office in Cambridge in December. She came to think that what people needed to heal themselves was a psychological “prime” — something that triggered the body to take curative measures all by itself. Gathering the older men together in New Hampshire, for what she would later refer to as a counterclockwise study, would be a way to test this premise. The men in the experimental group were told not merely to reminisce about this earlier era, but to inhabit it — to “make a psychological attempt to be the person they were 22 years ago,” she told me. “We have good reason to believe that if you are successful at this,” Langer told the men, “you will feel as you did in 1959.” From the time they walked through the doors, they were treated as if they were younger. The men were told that they would have to take their belongings upstairs themselves, even if they had to do it one shirt at a time. At the end of their stay, the men were tested again. On several measures, they outperformed a control group that came earlier to the monastery but didn’t imagine themselves back into the skin of their younger selves, though they were encouraged to reminisce. They were suppler, showed greater manual dexterity and sat taller — just as Langer had guessed. Perhaps most improbable, their sight improved. Independent judges said they looked younger. The experimental subjects, Langer told me, had “put their mind in an earlier time,” and their bodies went along for the ride.” Source: https://www.nytimes.com/2014/10/26/magazine/what-if-age-is-nothing-but-a-mind-set.html
  
• Live a life that has meaning – or, in other words, have a personal mission statement in life. Strive to accomplish something or to help others. “It is the pursuit of meaning is what makes human beings uniquely human. By putting aside our selfish interests to serve someone or something larger than ourselves -- by devoting our lives to "giving" rather than "taking" -- we are not only expressing our fundamental humanity, but are also acknowledging that that there is more to the good life than the pursuit of simple happiness.” Source: https://www.theatlantic.com/health/archive/2013/01/theres-more-to-life-than-being-happy/266805/
  
• Volunteer and help others. “Volunteering probably reduces mortality by a year and a half or possibly up to two years for people who are in their senior years,” says Stephen G. Post, a professor of preventive medicine at Stony Brook University School of Medicine and the author of The Hidden Gifts of Helping and Why Good Things Happen to Good People. “If you could put the benefits of helping others into a bottle and sell it, you could be a millionaire in a minute.” Source: https://www.thefreelibrary.com/Why+do+we+hesitate+to+help%3F-a0352848707
  
• Do strength training – there is an association between muscular strength and mortality in men (2008). Source: https://www.bmj.com/content/2/4225/927.4
  
• This is also a great book: 'How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease' by Michael Greger: https://www.goodreads.com/book/show/25663961-how-not-to-die . You can find a summary of it here: https://www.allencheng.com/how-not-to-die-by-michael-greger-summary/

The book you mention, Handbook of the Biology of Aging is probably the best I've run across for what you are looking for. It is very much like review articles. They cover the major research up to publication date (in 2015), and dive into specifics going over experimental design and methodologies.

A simpler, shorter, and more accessible intro for those who don't have your credentials is Biology of Aging. But if you wanted a very general sweep that is still focused on those with a biology education to supplement the deeper dive, this would be a good choice. (For example the Handbook of the Biology of Aging focuses on animal and human aging whereas the Biology of Aging has a section on plant senescence as well).

Laura Deming also has a good Longevity FAQ that covers the aging research landscape but more importantly for your needs contains links to papers and clinical trials at the bottom.

The best source is Natto.
You also need vitamin D3 to absorb the k2 fully

i found on Amazon a good source with K2 and D3 together.


I take mainly for the arteries.. I also tried the Natto. It is not as bad as it looks.

Molecular Biology of Aging. I own a copy and its a nice collection of seminal papers that acts as a great primer to learn about aging and longevity.

https://www.amazon.com/Molecular-Biology-SPRING-HARBOR-MONOGRAPH/dp/0879698241

This is an excerpt from a new book by Josh Mitteldorf and Dorion Sagan:

Cracking the Aging Code: The New Science of Growing Old-And What It Means for Staying Young

I haven't read the book yet, but I've been following the author's blog for several years. He has a unique, and I think convincing, take on why aging has evolved. His blog is my best source of information about new developments in curing aging.

I'm tired of reading the same longevity articles rehashed, too, but I posted this because it deserves to be seen.

It's reassuring to know that these tech billionaires really are afraid of death and that this is their motivation. This is because that motivation isn't likely to go away (until they cure death), and also because likely most tech billionaires will have the same fear and motivation to cure aging.

Has anybody read the book referred to in the article - Homo Deus? I wonder if the author's argument that Sergey Brin wont live to see aging conquered is a philosophical one (like John Gray's in 'The Immortality Commission') rather than scientific? https://www.amazon.com/Immortalization-Commission-Science-Strange-Quest/dp/0374533237

Well, Brin is 43 so 2 years younger than me. I believe the life expectancy of an average 43 y.o. American male right now is close to 80 or (37 more years of life). Given his wealth, his clear motivation to live as long as possible, and his access to the latest knowledge and science as to how to do so, I would suppose his life expectancy should be at least 85. So he has around a 50/50 chance of reaching 2060, given only current projections. With all the money and research being put into anti-aging, of which his efforts are a part, I would say it's quite pessimistic to state he wont live to see aging defeated by 2060.

Check out this book. The title and marketing campaign are a little hokey but it's chock full of research-backed ruminations on proper exercise and its health benefits. The chapter on global metabolic conditioning might break you out of the aerobic vs. anaerobic paradigm; they're not diametrically opposed but instead necessarily complement each other in any muscular contraction.

You can ask Aubrey de Grey [email protected] , hovewer, would you like to work in molecular nanotechnology? Make CAD program for designing nanomachines for medicine?

https://www.amazon.com/Nanomedical-Device-Systems-Design-Possibilities/dp/0849374987

A couple of years ago, in a talk, Aubrey waved two big books when the topic came up about how to get started. The books were:

• Essential Cell Biology
  
• Molecular Biology of the Cell
  
  (and SENS would most likely also recommend keeping Ending Aging handy).

Yes, I believe it is. As far as I know, all the present 'NAD precursors' have limited bio-availability and most longevity insiders don't believe they will do anything much. Jim Mellon, the author of Juvenescence, recommends we wait for David Sinclair's own product to come out, which is indeed supposed to be bio-available. Not sure what if any links he (Jim Mellor) might have to Sinclair.

​

There is one NAD supplement that Jim Mellor admits to taking daily, although he doubts its effectiveness. 'Basis' by Elysium, is backed by a number of Harvard professors (including George Church). It's supposed also to be more bio-available than most NAD precursors.

https://www.elysiumhealth.com/en-us/basis

​

https://www.amazon.com/Juvenescence-Investing-longevity-Mellon-Jim/dp/0993047815/

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The good news is that there are actually multiple, up-to-date textbooks on the biology of aging:

• Biology of Aging (2nd Edition) - Roger B. McDonald (Published 2019)
  
• Biology of Longevity and Aging: Pathways and Prospects - Robert Arking (Published 2019)
  
• Human Biological Aging: From Macromolecules to Organ Systems - Glenda E. Bilder (Published 2016)
  
  Caleb Finch also wrote a textbook, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans, but it was published in 2007 and hasn't been updated since. There's also the 8th Edition of the Handbook of the Biology of Aging, published in 2015.

Also The Alzheimer's Solution.

https://www.amazon.com/Relaxation-Response-Herbert-Benson/dp/0380006766

anyone tested this one?
https://www.amazon.co.uk/dp/B07TC7M13T/ref=cm_sw_em_r_mt_dp_U_GNhKDbP0DNGPD

Cardiovascular diseases and cancer are the leading causes of death.

• keep blood pressure in normal range
  
  
• keep homoscystine in check
  
  
• keep blood glucose in check
  
  
• do exercise that includes HIIT (improves collateral blood vessels)
  
  
• restrict calories
  
  
• eat enough fibre
  
  
• maintain normal weight range
  
  
• reduce salt
  
  
• stand rather than sit when working
  
  
• don't die in childbirth
  
  
• eat a range of antioxidant rich veges of different colours, to ensure you get enough nutrients and minerals. https://www.youtube.com/watch?v=Ys86ZgjQQYg
  
  
• avoid carcinogens eg processed meat
  
  
• read https://www.amazon.com/How-Not-Die-Discover-Scientifically/dp/1250066115
  
  
• read https://www.amazon.com/Blue-Zones-Lessons-Living-Longest/dp/1426207557